If you’ve ever had an autoimmune illness diagnosed, you’re probably familiar with what the anti-CCP test is and what it confirms. The prevalence of autoimmune illnesses has risen dramatically in recent years, owing to advances in diagnostic techniques and the development of several biomarkers.
There are a host of highly specific diagnostic tests now and for your rheumatoid arthritis or SLE. In contrast, the previous doctor had to recommend numerous blood tests, physical examinations, imaging tests, and so on, and the diagnosis was still based solely on its judgement and evaluation skills. The anti-CCP test is one such test that has recently received a lot of traction. Continue reading to learn more about its significance.
What is the Anti-CCP Test and how does it work?
The test detects the presence of anti-cyclic citrullinated peptides (Anti-CCP) antibodies, which are designed to attack citrullinated proteins found in the body. These proteins are frequently found in the joints. As a result, antibodies against this protein infiltrate the joints, causing degeneration and functional degradation. Anti-CCP testing is recommended by doctors for autoimmune diseases such as rheumatoid arthritis. Anti-CCP test findings are normally non-significant until they reach 20 u/ml or less, at which point they indicate the presence of rheumatoid arthritis.
The Anti-CCP Test’s Sensitivity and Specificity
Anti-CCP has a high specificity of more than 90% for rheumatoid arthritis, but it has a low sensitivity of less than 75%, according to studies. Simply put, two-thirds of individuals with rheumatoid arthritis may test negative for anti-CCP due to poorer sensitivity, while more than 90% of those who test positive likely have rheumatoid arthritis. The outcome can alternatively be read as follows:
A positive anti-CCP test in a healthy person raises the risk of rheumatoid arthritis developing quickly.
A positive anti-CCP test in patients with early-stage RA helps confirm the diagnosis.
Anti-CCP positivity in chronic RA patients signifies a serious degenerative disease.
Continue reading if you want to learn more about the anti-CCP test and when you will take it.
When Should You Have an Anti-CCP Test Performed?
If you have any of the following symptoms, you should have an Anti-CCP test, such as:
stiff in the morning
Unusual joint discomfort
Swelling in bones that is unusual
Low-grade fever that persists
To summarise, early diagnosis of autoimmune illnesses is critical for receiving the appropriate treatment at the appropriate time. The presence of C-reactive proteins, synovial fluid analysis, erythrocyte sedimentation rate, and other tests may be indicated in additional to anti-CCP to establish the state and stage of knee degradation. Anti-CCP, on the other hand, is thought to be highly specific for RA.
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